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Excellent LC-MS Separation of Penicillins and Cephalosporins Using Ultra IBD Columns

Unlike C18 columns, Ultra IBD (intrinsically base deactivated) columns can interact in normal phase mode with analytes that possess charged functional groups, providing greater versatility for LC-MS analyses. Excellent peak shape in either normal phase mode or reversed phase mode increases sensitivity and improves quantification. The 4-page note shows example analyses of penicillins and cephalosporins.

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